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Writer's pictureNeurology Associates

Does Smoking Have a Negative Impact on Brain Health?

A senior man not minding the negative impacts of smoking to the brain health.

Smoking is widely known to harm various organs in the body, but its effects on the brain are often overlooked. Several recent studies have shed light on the significant negative impact smoking can have on brain health.


Read on as we explore the relationship between smoking and brain health, addressing some common questions and concerns.


How Does Smoking Negatively Affect Your Brain?

The brain, as the control center of our body, influences every aspect of our lives, from cognitive abilities and emotional regulation to decision-making and overall quality of life.


When smoking compromises brain health, it can have ripple effects across all areas of an individual's life.


Here are 9 significant ways in which smoking negatively affects brain health:


1. Brain Tissue Thinning

Smoking causes the outer layer of the brain, called the cortex, to become thinner over time. Think of the cortex as the brain's "thinking cap"-- it's responsible for many important functions like decision-making and memory [1].


When you smoke, this layer gets thinner faster than it would with normal aging. The more cigarettes you smoke and the longer you smoke, the thinner this important brain layer becomes.


2. Loss of Grey Matter

Grey matter is the "meaty" part of your brain containing most of the brain's nerve cells. It's crucial for processing information, controlling muscles, and regulating emotions. Smoking reduces the amount of grey matter in various parts of the brain [3].


Surprisingly, this effect has been seen even in young smokers under 30 years old [1]. This means that smoking can age your brain prematurely.


3. Shrinkage of Multiple Brain Areas

Yes, smoking causes brain shrinkage. Long-term smoking doesn't just affect one part of the brain--it causes several important areas to shrink.


These include the insula (involved in emotions and cravings), cerebellum (important for movement and balance), parahippocampus (crucial for memory), prefrontal cortex (responsible for decision-making and personality), and thalamus (relays sensory information) [1]. This widespread shrinkage can affect many aspects of a person's thinking and behavior.


4. Altered Functional Connectivity in Brain Networks

Our brains consist of various interconnected networks that work together to process information and regulate behavior. These are the Default Mode Network (DMN), Executive Control Network (ECN), and Salience Network [1,2].


Smoking has been shown to disrupt the functional connectivity within and between these networks.


These disruptions in functional connectivity can lead to a range of cognitive and behavioral issues, including:


  • Impaired attention and concentration

  • Difficulties with decision-making and problem-solving

  • Reduced cognitive flexibility

  • Altered emotional processing and regulation


5. Impaired Memory and Thinking Speed

Smokers often experience a decline in cognitive abilities, especially in areas like verbal memory (remembering words and language) and processing speed (how quickly you can understand and react to information) [3].


This means that smokers might find it harder to remember conversations or take longer to solve problems, particularly as they get older.


6. Weakened Self-Control and Risk Assessment

Smoking affects the brain circuits responsible for self-control and evaluating risks. This means smokers might find it harder to resist impulses or might make riskier decisions without fully considering the consequences [4]. It's like the brain's "brake system" becomes less effective.


7. Increased Risk of Alzheimer's Disease

Smoking may make the brain more vulnerable to Alzheimer's disease. It does this by reducing the brain's "reserve" of acetylcholine, a chemical important for memory. 


Smokers tend to have a smaller basal forebrain (an area that produces acetylcholine), which could make them more susceptible to memory problems and Alzheimer's disease later in life [4].


8. Accelerated Brain Aging

In older adults, smoking speeds up the natural aging process of the brain. It causes brain tissue to waste away (atrophy) faster, especially in areas affected by Alzheimer's disease [1].


This means that a smoker's brain might "age" faster than their actual years.


9. Harmful Effects on Developing Brain

When pregnant women smoke, it can harm their unborn child's brain development. Children exposed to smoke in the womb may have problems with self-control and may be more likely to engage in risky behaviors. 


It's like the smoke interferes with the brain's "impulse control" system before the child is even born [1].



Effects of Nicotine on the Adolescent Brain

Adolescence is a critical period of brain development, making it particularly vulnerable to the effects of smoking and nicotine exposure [4]. Here's why smoking during the teenage years can have such significant and long-lasting impacts:


  • Crucial Developmental Stage

    During adolescence, the brain undergoes substantial changes, especially in areas responsible for executive function, working memory, reward processing, emotional regulation, and motivated behavior.


    These regions are still developing, making them highly susceptible to external influences like nicotine.


  • Enhanced Sensitivity to Nicotine

    The teenage brain is more sensitive to nicotine than the adult brain. This is due to increased expression and activity of nicotinic acetylcholine receptors (nAChRs) in adolescent brains, particularly in areas like the nucleus accumbens, amygdala, and prefrontal cortex [4].


    This heightened sensitivity makes teenagers more vulnerable to nicotine addiction.


  • Long-term Structural and Functional Changes

    Chronic nicotine exposure during adolescence can lead to lasting alterations in the brain's structure and function. Studies on rodent models, which have similar brain developmental patterns to humans, show that teenage nicotine exposure can cause enduring changes in dopamine and serotonin systems [4].


    These neurochemical alterations may contribute to an increased risk of mental health disorders, cognitive impairments, and difficulties with impulse control later in life.


  • Increased Vulnerability to Addiction

    The enhanced sensitivity of the adolescent brain to nicotine, combined with the ongoing development of impulse control and decision-making abilities, makes teenagers particularly susceptible to nicotine addiction [4].


    This can set the stage for long-term smoking habits and associated health risks.


Smokers Should Seek Medical Advise ASAP

Given the severity and wide-ranging nature of these effects, it's crucial for smokers, especially long-term or heavy smokers, to seek professional medical advice. We highly recommend consulting with a neurologist to assess your brain health and develop a personalized plan for mitigation and recovery.


This is equally important for those who have recently quit smoking, as a neurological consultation can be particularly beneficial in monitoring recovery and addressing any lingering effects. While quitting smoking can lead to some recovery, the best approach is to avoid smoking altogether, especially during adolescence when the brain is particularly vulnerable.


For Americans in Arizona, the Neurology Associates Neuroscience Center, with locations in Chandler, Mesa, and available telehealth services, is a noteworthy option. They are recognized for their holistic approach to neurological care, offering patients access to skilled specialists and advanced treatment options. 


References

[1] Boksa, P. (2017). Smoking, psychiatric illness and the brain. Journal of Psychiatry & Neuroscience, 42(3), 147–150. https://doi.org/10.1503/jpn.170060


[2] Karama, S., Ducharme, S., Corley, J., Chouinard-Decorte, F., Starr, J. M., Wardlaw, J. M.,… Deary, I. J. (2015). Cigarette smoking and thinning of the brain’s cortex. Molecular Psychiatry, 20(6), 778–785. https://doi.org/10.1038/mp.2014.187


[3] Nooyens, G., Almeida, O. P., Hankey, G. J., Hulse, G. K., Flicker, L., & Lautenschlager, N. T. (2011). 24-Month effect of smoking cessation on cognitive function and brain structure in later life. NeuroImage, 55(4), 1480–1489. https://doi.org/10.1016/j.neuroimage.2011.01.063[4] Yuan, M., Cross, S. J., Loughlin, S. E., & Leslie, F. M. (2015). Nicotine and the adolescent brain. The Journal of Physiology, 593(16), 3397–3412. https://doi.org/10.1113/JP270492



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